Shown are fibroblasts from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. The morphology of the envelop...

Shown are a normal human fibroblasts stained for lamin A (red), a major component of the nuclear lamina. Other images in this group show the envelope abnormalities that occur in HGPS patients carryin...

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (left image, red), a major component of the nuclear lamina. Also shown is th...

Shown is an image of a thin section showing the ultrastructure of the nucleus and nuclaer envelope in fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gen...

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. Also shown is the distributi...

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a truncation in the gene for lamin A (red, left image), a major component of the nuclear lamina. The distributio...