The unique-6 (U6) motif of the MAGUK protein, ZO-1, inhibits tight junction localization of GFP fusion proteins containing the SH3-GUK module. Stable MDCK II cell lines expressing GFP fusion proteins ...

This is a view of apical domains of two adjacent hepatocytes showing the junctional complexes that attach cells to one another. The canaliculus is defined by the cell membranes of two adjacent liver c...

This is a view of apical domains of two adjacent hepatocytes in the guinea pig liver, showing the junctional complexes that attach cells to one another. The bile canaliculus (BC) is defined by the cel...

The unique-5 (U5) and unique-6 (U6) motifs of the MAGUK protein, ZO-1 are required for localization of ZO-1 to the apical tight junction. Cell lines expressing the myc-tagged transgenes ZO1-FL (A and ...

Transmembrane proteins of the tight junction (occludin, claudin-2, JAM-A), but not cytosolic proteins (cingulin, ZO-2, alpha-catenin), are incorporated into the ectopic strands formed by delta-U6 cons...

Cell expressing delta U6 ZO-1 constructs show novel freeze fracture strands extending onto the lateral membrane. Stable MDCK cell lines were fixed and analyzed by freeze fracture electron microscopy. ...