Alternate header for print version


Licensing
Attribution Non-Commercial Share Alike:This image is licensed under a Creative Commons Attribution, Non-Commercial Share Alike License. View License Deed | View Legal Code
tweet  
*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:54469*  Cite 
Description

Pathology load assessment of de-identified, human, post-mortem Alzheimer's disease and age-matched non-symptomatic donor prefrontal cortex brain tissue. We used these imaging data to inform donor stratification when we generated a large single nuclei RNA sequencing (snRNA-seq) dataset. Given we generated both imaging and snRNA-seq datasets the same location/piece of tissue for each donor, this gives us an unprecedented platform to evaluate cell type/subpopulation transcriptomes and relate them directly to their respective tissue microenvironments.

Technical Details

5 um sections of FFPE prefrontal cortex tissue from post-mortem, human Alzheimer's disease donor labeled for phosphorylated tau (AT8)

Biological Sources
NCBI Organism Classification
Homo sapiens
Cellular Component
phosphorylated tau (AT8)
Biological Context
Biological Process
Alzheimer's disease patient
Attribution
Names
Jessica S. Sadick
Shane A. Liddelow
OTHER
central nervous system
brain
Citation
Digital Object Identifier (DOI)
doi:10.7295/W9CIL54469
Archival Resource Key (ARK)
ark:/b7295/w9cil54469
Grouping This image is part of a group.
Imaging
Image Mode
bright-field microscopy
Visualization Methods
AT8 IHC using HRP/DAB