Tranmission electron micrograph of a representative untreated sac1∆ mutant cell. SAC1 encodes a phosphatase that converts phosphatidylinositol 4-phosphate (PIP) to phosphatidylinositol (PI). sac1∆ mutant cells have fewer normal vacuoles than wildtype. (10,000X). An image of the same mutant treated with sertraline is available as CIL 40433.
This group of images contains representative whole-cell images and high-magnification zooms of organelle structures of interest. All cells were grown in liquid rich media (YPD pH6.5) at 30C with aerated shaking, and cultures were sampled in mid-logarithmic phase. Treated cells were exposed to 60µM antidepressant sertraline (Zoloft®) for 45 minutes.
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