Transmission electron micrograph of a representative untreated arf1Δ mutant cell. ARF1 encodes a small regulatory GTPase that nucleates vesicle formation in the early secretory pathway. The fenestrated structures represent aberrant Golgi. (8,000X). A sertraline treated cell is available as CIL 40411.
This group of images contains representative whole-cell images and high-magnification zooms of organelle structures of interest. All cells were grown in liquid rich media (YPD pH6.5) at 30C with aerated shaking, and cultures were sampled in mid-logarithmic phase. Treated cells were exposed to 60µM antidepressant sertraline (Zoloft®) for 45 minutes.
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