Transmission electron micrograph of a representative sertraline-treated arf1Δ mutant cell. ARF1 encodes a small regulatory GTPase that nucleates vesicle formation in the early secretory pathway. The circular organelles appear to be aberrant Golgi. (5,000X). The untreated control is CIL 40412.
This group of images contains representative whole-cell images and high-magnification zooms of organelle structures of interest. All cells were grown in liquid rich media (YPD pH6.5) at 30C with aerated shaking, and cultures were sampled in mid-logarithmic phase. Treated cells were exposed to 60µM antidepressant sertraline (Zoloft®) for 45 minutes.
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