Licensing

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*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:38996^* Cite

Description

Transmission electron micrograph showing collagen fibrils exhibiting focal swelling and loss of periodic cross banding in the trabecular meshwork of a person with glaucoma. The trabecular meshwork is the structure through which the aqueous humor in the anterior chamber drains into Schlemm's canal. The obstruction of this process may represent a mechanism by which the intraocullar pressure is raised in glaucoma. The proteoglycans that are normally attached to the collagen fibrils have become detached and are seen as small short filaments. The intact fibrils are approximately 120 nm in diameter.

Technical Details

B0001823 Degenerating collagen fibrils in glaucoma. Wellcome Images available under the following creative commons usage http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

Biological Sources

NCBI Organism Classification: Homo sapiens
Cellular Component: extracellular matrix; collagen

Biological Context

Biological Process: collagen fibril organization
Human Development Anatomy: trabecular meshwork
Human Disease: glaucoma

Attribution

Names: Rob Young
Link: Wellcome Images

Citation

Digital Object Identifier (DOI): doi:10.7295/W9CIL38996
Archival Resource Key (ARK): ark:/b7295/w9cil38996

Grouping This image is part of a group.

Imaging

Image Type: recorded image
Image Mode: transmission electron microscopy (TEM)
Parameters Imaged: electron density
Source of Contrast: differences in adsorption or binding of stain
Visualization Methods: uranyl salt; cationic dye
Processing History: unprocessed raw data

Sample Preparation

Methods: chemically fixed tissue
Relation To Intact Cell: sectioned tissue

Dimensions

Spatial Axis	Image Size	Pixel Size
X	774px	——
Y	576px	——