Licensing
Description
Transmission electron micrograph of a tangential section of a rat glomerulus basement membrane. The series of images in this group have particular historic and cell biologic importance for determining the role of the glomerular basement membrane in urinary filtration, especially the charge properties and size selectivity in retention of proteins in the circulation. The images here clearly show the glomerular filtration barrier. The study also elucidated the role of the basement membrane in some forms of nephrosis. Image made available by James D. Jamieson and the Department of Cell Biology, Yale University School of Medicine.
Technical Details
Relevant citations: Kanwar, Y.S. and M.G. Farquhar. 1979. J. Cell Biol. 81:137-153. Farquhar, M.G., S.L. Wisssig and G.E. Palade. 1961 . J. Exp. Med. 113:47-66. Original 3.25 in. x 4 in. lantern slides were scanned at 600dpi. Original magnification X18,000.
Biological Sources
- NCBI Organism Classification
- Rattus
- (Old World rats)
- Cell Type
- kidney cell
- glomerular endothelial cell
- podocyte
- Cellular Component
- basement membrane
Biological Context
- Biological Process
- glomerular filtration
Attribution
- Name
- Marilyn G. Farquhar
- Link
- George E. Palade EM Slide Collection
- Date
- 00/17/1962
Grouping
This image is part of a group.Imaging
- Image Type
- recorded image
- Imaging Mode
- transmission electron microscopy (TEM)
- Parameters Imaged
- electron density
- Source of Contrast
- differences in adsorption or binding of stain
Sample Preparation
- Methods
- osmium tetroxide fixed tissue
- Relation To Intact Cell
- sectioned tissue
Dimensions
| Spatial Axis | Image Size | Pixel Size |
|---|---|---|
| X | 6000px | —— |
| Y | 5132px | —— |