Alternate header for print version


Licensing
Public Domain: This image is in the public domain and thus free of any copyright restrictions. However, as is the norm in scientific publishing and as a matter of courtesy, any user should credit the content provider for any public or private use of this image whenever possible. Learn more
tweet  
*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:220*  Cite 
Description

Molecules designed to block the expanded CAG repeats characteristic of Huntington's disease fluoresce blue in these cultured cells and prevent the expression of the mutant proteins that cause the disease.

Technical Details

See: J. Hu et al.(2009) Allele-specific silencing of mutant huntintin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol 27:478-484.

Biological Sources
NCBI Organism Classification
Mus musculus
Cell Type
neuron
Biological Context
Human Disease
Huntington's disease
Attribution
Names
Jiaxin Hu
David Dodd
Robert Hudson
Link
NIGMS Biomedical Beat
Citation
Digital Object Identifier (DOI)
doi:10.7295/W9CIL220
Archival Resource Key (ARK)
ark:/b7295/w9cil220
Imaging
Image Type
recorded image
Image Mode
fluorescence microscopy
Parameters Imaged
fluorescence emission
Data Qualifiers
processed data
Sample Preparation
Relation To Intact Cell
whole mounted tissue
Dimensions
Spatial Axis Image Size Pixel Size
X 688px ——
Y 512px ——