The Cell: An Image Library

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CIL:220^*

Description

Molecules designed to block the expanded CAG repeats characteristic of Huntington's disease fluoresce blue in these cultured cells and prevent the expression of the mutant proteins that cause the disease.

Technical Details

See: J. Hu et al.(2009) Allele-specific silencing of mutant huntintin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol 27:478-484.

Biological Sources

NCBI Organism Classification: Mus musculus; (house mouse)
Cell Type: neuron

Biological Context

Human Disease: Huntington's disease

Attribution

Names: Jiaxin Hu; David Dodd; Robert Hudson
Link: NIGMS Biomedical Beat

Imaging

Image Type: recorded image
Imaging Mode: fluorescence microscopy
Parameters Imaged: fluorescence emission

Data Qualifiers: processed data

Sample Preparation

Relation To Intact Cell: whole mounted tissue

Dimensions

Spatial Axis	Image Size	Pixel Size
X	688px	——
Y	512px	——

*CIL – Cell Image Library accession number. Please use this to reference an image.