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Description

Example of human chromosome labeling and identification using multi-color fluorescence in situ hybridization (FISH) with probes specific for the DNA of individual chromosomes. Using this chromosome paining technique, each chromosome can be given a unique color. Shown are chromosomes from a patient with Werner Syndrome in which a genetic abnormality is seen in the central maroon-colored chromosome with a segment translocated from another chromosome - seen as the gold tip.

Biological Sources

NCBI Organism Classification
Homo sapiens
(human)
Cellular Component
nuclear chromosome

Biological Context

Biological Process
chromosome translocation
mitotic metaphase
Human Disease
Werner syndrome

Attribution

Name
Anna Jauch
Link
BioMedical Beat

Imaging

Image Type
recorded image
Imaging Mode
fluorescence microscopy
Parameters Imaged
fluorescence emission
Source of Contrast
distribution of a specific nucleic acid sequence
Visualization Methods
Multicolor FISH
Data Qualifiers
processed data

Sample Preparation

Methods
Chromosome spread

Dimensions

Spatial Axis Image Size Pixel Size
X 395px ——
Y 351px ——
*CIL – Cell Image Library accession number. Please use this to reference an image.